Open the Activity Monitor and see what %CPU is showing when you see this
activity.
Right now my Microsoft Database daemon is showing 0%.
The daemon is also tied to sync services. Try turning off Spotlight in
Entourage preferences and see if that helps.
Basics:
Spotlight will index any cache files the Entourage daemon has created even
if the daemon is not launched, but no new cache files will be created until
the daemon is launched again. If the Microsoft Sync daemon never launches,
there's no way for Entourage to sync data with Sync Services. The
preferences in Entourage for Sync Services basically control 1) if this
daemon app is launched and 2) where it should sync data to-from.
To help performance, add your Identities folder to Spotlight Exclude list.
See this page for more tips to help performance. Entourage has a different
mechanism to provide Spotlight information for e-mails and contacts so you
don't loose this functionality by excluding the database.
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http://www.entourage.mvps.org/troubleshoot/performance.html#options_perform
ance>