Entourage doesn't have and never did have an Out of Office Assistant. If
you are accessing mail from an Exchange Server, you can use Outlook Web
Access or Microsoft Outlook software to configure the server-level Out of
Office Assistant to your needs.
Otherwise, see this FAQ article:
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http://www.entourage.mvps.org/rules/example/rule003.html>
Make sure that you read the note at the bottom. If you don't want to or
cannot keep your computer on and internet connection active while you're
away, you should investigate to see if there is a server-level auto reply
function that you can use.