What version Publisher are you using?
2003 and below, Page setup, Business cards, click *Change copies per page*...
Type:
..5 side
..75 top
..5 Horizontal Gap
..5 Vertical Gap
This setup will print with crop marks, if you don't want the marks, on the print
screen click *Advanced Print Settings*
2007, File, Page setup, Advanced (on the right) select *Multiple pages per
sheet*, change the margins to those above. Give the setup a name, it will be
available next time you need it. Again you will have to uncheck crop marks in
the Advanced Print settings if you don't want them to print.