Microsoft office and microsoft entourage are not opening! What should I do?
Testing in a new User will quickly tell you if the problem is system wide or
if it's your User's folder that contains the problem.
Go to System Preferences --> Create a New User in Accounts. Switch to the
New User by logging out/in or use Fast User Switching. Test Office there.
Let us know what happens in the new User. We are going to need more details
than you provided.