If you data begins on A1 on a separate area on worsksheet enter
=if(A1>0,-1*a1,a1)
Copy this formula across all the rows and columns
Then select this block of data , copy it and on cell A1 go to Edit>Paste
special -> values
Highlight the range of cell values you wish to change
Select Edit/Paste Special and check the Multiply option
Click OK
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