MDE is an Access file format offering full operational functionality,
but no design capabilities and no source code; it is produced converting
the .mdb design master, and is used for distribution to users for the
very reason that it does not allow design changes.
Officially, there is no way to make design changes / additions in an
..mde. To do that, you need to have the .mdb it was created from, make
your changes there, and recreate the new .mde. So, in theory, if you've
lost the .mdb, there is not much you can do, other than starting from
scratch!
Unofficially, there are third party tools that offer some unlocking
functionality, so you can salvage some parts of the design in the
absence of the original .mdb. I said "some" because, to the best of my
knowledge, they will provide access to the design of forms and reports,
but not to code, because no source code exists in an .mde; not sure
about macros. If interested, do a Google search on "Access mde unlock".
HTH,
Nikos