Jon --
If you wish to use the Resource Substitution Wizard, you will need to create
a Generic resource to match each skill set. When you are planning a
project, assign Generic resources to those tasks in you are not certain as
to exactly which human resource will work on the task. You should also set
the "R/D" field to "Demand" for each resource assignment to tasks which use
a human resource, unless you want the Resource Substitution Wizard to
consider those assignments for subsituting a different human resource.
To test the matching of human resources with Generic resources, I like to
use the Match button in the Team Builder Wizard to make sure that the
correct human resources match each Generic resource. To use this feature,
run the Wizard, then copy a Generic resource from the left side to the right
side. Click the Match button and analyze which human resources were
selected. Hope this helps.