Yes: create a query to feed the report, and put the calcuation in the query.
In query design view, you can enter a calculation into the Field row of the
grid, e.g.:
Amount: Quantity * PriceEach
Then use that query as the RecordSource of your report, and you can use the
Amount field just like any other field.
If you get all that working, but the sorting is not what you expect, see:
Calculated fields misinterpreted
at:
http://allenbrowne.com/ser-45.html