You would have to use a letterbox frameset arrangement to achieve that. For
example, create a frameset containing these frames (each digit stands for a
separate frame) -
111111111
223333344
223333344
223333344
555555555
Frames 1, 2, 4, and 5 all need to be flexible. Frame 3 will stay
horizontally and vertically centered if you give it an explicit width and
height.
HOWEVER - The reason for using or not using frames should be based on a)
your site's needs, and b) your willingness to accept the potential problems
that frames can create for you as developer and maintainer of the site and
for your visitors as casual users of the site.
I am down on frames because I believe that they create many more problems
than they solve.
Judging from the posts here, and the kinds of problems that are described,
the kind of person most likely to elect to use frames is also the kind of
person most likely ill-prepared fo solve the ensuing problems when they
arise. If you feel a) that you understand the problems and b) that you are
prepared to handle them when they occur, and c) that you have a need to use
frames, then by all means use them.
As far as I know, the most comprehensive discussions of frames and their
potential problems can be found on these two links -
http://apptools.com/rants/framesevil.php
http://www.tjkdesign.com/articles/frames/