Use the Mail Merge feature if it's just different addresses you need.
If you need entirely different designs, you'll need to manually set up your
labels on a larger page. Set the page size in File > Page Setup to the size
of your sheet of labels, and then set the layout guides to the positions of
the individual labels.
Setup your page manually. Basically postcards are setup with two rows and two
columns, landscaped. You will have to configure your margins. This will be the
trickiest part of your creation.
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