I believe from previous experience that if an account is not setup, Outlook
will prompt you to set one up and even if you don't it will open with a bare
bones Personal Folders file that you can use for tasks, contacts, calender,
etc.
But to answer the question, yes, I had it setup with several email accounts
and it was working fine for months. It crashed while I was adding a contact
to my contact list. But, I was able to use a backup profile that I had
created before and successfully run OL. Then I tried to open my original PST
and it told me there was an error in the PST and I needed to run ScanPST.exe.
I had to search the whole computer to find ScanPST but I did and ran it on
the old PST. It repaired it (supposedly) and then I was able to run OL with
my normal profile. I don't know what damage was done but I don't see anything
missing from my normal PST yet.
So I eventually fixed it but MS Office certainly doesn't make it easy.
Outlook apparently can't run in a backup mode if the main PST folder is
corrupted and the error message was ridiculously unhelpful. (Where did it
come up with this fictitious "server" it was talking about?). Finally, I had
to do a file search over my entire 100GB hard drive to find the utility to
fix it.